Optimized Nanoparticles for Enhanced Oral Bioavailability of a Poorly Soluble Drug: Solid Lipid Nanoparticles Versus Nanostructured Lipid Carriers.

Manal K M Darwish,Amal S M Abu El-Enin,Kamilia H A Mohammed

Pharmaceutical nanotechnology（2022）

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摘要

ROSCa was successfully encapsulated in SLNs and NLCs. The optimized NLCs formulation showed improved quality attributes compared to SLNs. Thus, NLCs loaded formulations could be an effective oral drug delivery system to enhance the bioavailability of insoluble drugs.

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关键词

Box-Behnken design,Rosuvastatin,clinical evaluation,entrapment efficiency,nanostructured lipid carriers,optimization,oral bioavailability,particle size,solid lipid nanoparticle

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