The Blood-Brain Barrier Models to Study Apolipoprotein E Genotypes in Alzheimer's Disease.

Alzheimer's disease (AD) is a neurodegenerative disease that is characterized by an age-dependent progressive decline of memory,impairment of cognitive functions and changes in personality and behavior.Despite the improvement in understanding of the mechanisms underlying the disease,AD remains an incurable complex disorder with multifaceted pathophysiology to date.