Class Distance Weighted Cross-Entropy Loss for Ulcerative Colitis Severity Estimation.

Endoscopic Mayo score and Ulcerative Colitis Endoscopic Index of Severity are commonly used scoring systems for the assessment of endoscopic severity of ulcerative colitis. They are based on assigning a score in relation to the disease activity, which creates a rank among the levels, making it an ordinal regression problem. On the other hand, most studies use categorical cross-entropy loss function, which is not optimal for the ordinal regression problem, to train the deep learning models. In this study, we propose a novel loss function called class distance weighted cross-entropy (CDW-CE) that respects the order of the classes and takes the distance of the classes into account in calculation of cost. Experimental evaluations show that CDW-CE outperforms the conventional categorical cross-entropy and CORN framework, which is designed for the ordinal regression problems. In addition, CDW-CE does not require any modifications at the output layer and is compatible with the class activation map visualization techniques.