[Effect of Dimethyl Fumarate (DMF) on T-cell Acute Lymphoblastic Leukemia].

Jin-Ge Xu,Qiao Cheng,Gui-Hua Zhang,Li-Ping Kong,Li Li,Kai-Ge Liu,Jin-Yan Wu,Qiu-Rong Zhang

Zhongguo shi yan xue ye xue za zhi（2022）

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摘要

DMF inhibits the proliferation of T-cell acute lymphoblastic leukemia cell. The mechanism may be that, DMF significantly up-regulates the protein levels of Nrf2 and E3 ubiquitin ligase HACE1, and HACE1 interacts with Nrf2 and positively regulates Nrf2 protein level.

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关键词

HACE1,T-cell acute lymphoblastic leukemia,dimethyl fumarate,nuclear factor-erythroid 2-related factor 2

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