Diagnostic and prognostic implications of tumor expression of the GATA-3 gene in nodal peripheral T-cell lymphoma (nPTCL): Retrospective data from a Latin American cohort

•GATA-3 gene overexpression by RT-PCR in FFPE samples may be an important biomarker associated with poor-prognosis in nPTCL.•Tissue levels of the GATA-3 gene expression may help to discriminate the histological variants of nPTCL.•High tumor expression of the GATA-3 gene was associated with poor OS in patients with PTCL, NOS and ALK negative ALCL.•GATA-3 overexpression was associated with B-symptoms, high-risk PIT, poor ORR and high-mortality in PTCL, NOS.•Overexpression of the GATA-3 gene was an independent factor associated with decreased OS in nPTCL Latin American patien.