Estimation of zorifertinib metabolic stability in human liver microsomes using LC–MS/MS

Mohamed W Attwa,Nasser S Al-Shakliah,Haitham AlRabiah,Adnan A Kadi,Ali S Abdelhameed

Journal of Pharmaceutical and Biomedical Analysis（2022）

引用 7|浏览4

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摘要

•This is considered the first LC-MS/MS method for ZFB quantification in the HLMs matrix.•ZFB metabolic stability prediction was done using the StarDrop software package (WhichP450 module).•The ZFB metabolic stability including CLint (32.5 µL/min/mg) and in vitro t1/2 (21.33 min).•ZFB showed a moderate extraction ratio that reveals its good in vivo bioavailability.

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关键词

ZFB,ENF,IS,ESI,HLMs,BBB,CNS,CLint,TKIs,LC-MS/MS,EGFR,NSCLCs,Clint,t1/2

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