Multiscale structural mapping of Alzheimer’s disease neurodegeneration

•A multiscale structural mapping (MSSM) procedure is proposed for the quantification of neurodegeneration in Alzheimer's disease using a single structural brain image.•The MSSM procedure captures both macrostructural properties and indirect index of tissue microstructure throughout the cerebral cortex.•The MSSM procedure provides enhanced ability for the detection of degeneration in Alzheimer’s disease and mild cognitive impairment compared to traditional measures such as cortical thickness and hippocampal volume and therefore may provide a sensitive measure of Alzheimer’s disease neurodegeneration.