The anti-inflammatory activity by suppressing the TRAF6/MAPKs pathway of trishizukaol a from Sarcandra glabra

•The anti-inflammatory effect of trimeric lindenane-type sesquiterpenoids from Sarcandra glabra (S. glabra) was first investigated.•For the first time, lindenane-type sesquiterpenoids were confirmed might exert anti-inflammatory effects by targeting to TRAF6.•An abundant trimeric lindenane-type sesquiterpenoid in S. glabra, Trishizukaol A could serve as a potential candidate for inflammatory diseases.