Impact of continuous pharmacist intervention for injectable antimicrobials on the treatment of patients with Escherichia coli bacteremia

•We examined the audit by pharmacists in whole antibiotics for E. coli bacteremia.•Antimicrobial use was reduced 29% by pharmacist intervention after three years.•Anti-pseudomonal drug use was reduced by 42% after three years intervention.•Pharmacists’ intervention was reduced costs by 24% without changing mortality.