6‑Iodopurine as a Versatile Building Block for RNA Purine Architecture Modifications
Bioconjugate Chemistry(2022)
摘要
Natural modified bases in RNA were found to be indispensable for basic biological processes. In addition, artificial RNA modifications have been a versatile toolbox for the study of RNA interference, structure, and dynamics. Here, we present a chemical method for the facile synthesis of RNA containing C6-modified purine. 6-Iodopurine, as a postsynthetic building block with high reactivity, was used for metal-free construction of C–N, C–O, and C–S bonds under mild conditions and C–C bond formation by Suzuki–Miyaura cross-coupling. Our strategy provides a convenient approach for the synthesis of various RNA modifications, especially for oligonucleotides containing specific structures.
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关键词
rna
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