IL-4 plays an essential role in DnaJ-ΔA146Ply-mediated immunoprotection against Streptococcus pneumoniae in mice

Yi Hu,Lian Li,Wenchun Xu,Kaifeng Wu,Jiangming Xiao,Yang Peng,Yusi Liu,Yibing Yin,Xuemei Zhang

Molecular Immunology（2022）

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摘要

•IL-4 does not affect DnaJ-ΔA146Ply-mediated antibody production or effect.•IL-4 deficiency changes cellular immune response induced by DnaJ-ΔA146Ply.•IL-4 enhances opsonic phagocytosis of neutrophils partially by activating Syk.

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关键词

IL-4,DnaJ-ΔA146Ply,Streptococcus pneumoniae,Protection

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