Reconstruction of regulatory network predicts transcription factors driving the dynamics of zebrafish heart regeneration
Gene(2022)
Abstract
•135 transcription factors were reported to drive the cellular state transition process during zebrafish cardiac regeneration.•Most regulators are activated in the first post-injury days indicating that the transition from a non-regenerative to a regenerative state occurs promptly.•The cardiac regeneration program interferes with the microRNA machinery.
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Key words
Regeneration,Heart,Regulation,Transcription factors,Danio rerio
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