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Apolipoprotein E genotypes modulate neuroinflammatory and vascular pathology in hyperhomocysteinemia-induced VCID.

Charles E Seaks,Erica M Weekman,Tiffany L Sudduth,Teodoro Bottiglieri,Lance A Johnson,Donna M Wilcock

Alzheimer's & dementia : the journal of the Alzheimer's Association（2021）

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Abstract
Our results demonstrate significant differences in how ApoE3/3 and ApoE4/4 mice respond to HHcy conditions on a pathological, gene expression, and metabolic level. Our neuroinflammatory data suggest that the ApoE4 mice were less reactive to neuroinflammatory stimulus than their ApoE3/3 counterparts.
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vcid,genotypes,vascular pathology
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