Diet and APOE as moderators of the relationship between trimethylamine N-oxide and biomarkers of Alzheimer's disease and glial activation.

John C Thorstenson,Margo B Heston,Katie R Zarbock,Cynthia M Carlsson,Corinne D Engelman,Yuetiva Deming,Sterling C Johnson,Tyler K Ulland,Sanjay Asthana,Gwendlyn Kollmorgen,Ivonne Suridjan,Kaj Blennow,Henrik Zetterberg,Nathaniel A Chin,Federico E Rey,Barbara B Bendlin

Alzheimer's & dementia : the journal of the Alzheimer's Association（2021）

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摘要

This study suggests that CSF carnitine reflects dietary intake, and may drive the TMAO-sTREM2 association previously identified. Future studies in animal models are required to confirm these results mechanistically.

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alzheimer,biomarkers,diet

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