The relationship between first-degree family history of dementia, tau pathology and functional impairment among brain donors at risk for chronic traumatic encephalopathy.

Evan S Nair, Rebecca Burton,Bobak Abdolmohammadi,Nicole Saltiel,Madeline Uretsky,Arsal Shah,Zachary H Baucom,Brett M Martin,Joseph Palmisano,Bertrand R Huber,Jonathan D Cherry,Victor E Alvarez,Michael L Alosco,Yorghos Tripodis,John F Crary,Thor D Stein,Ann C McKee,Jesse Mez

Alzheimer's & dementia : the journal of the Alzheimer's Association（2021）

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摘要

Among brain donors with RHI exposure, hippocampal CA4 tau burden may mediate the relationship between first-degree FH of dementia and functional impairment. The findings suggest that the risk of CTE may be heritable and share etiologic mechanisms with other dementing illnesses.

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