Amyloid-β analysis from brain cells using microfluidics and mass spectrometry.

The LCM-MIMAS approach could overcome the current limitations of accessing protein cell content, allowing the study of Aβ from brain cells. The Aβ characterization will facilitate the optimization of the assay. We plan to study soluble Aβ species from specific cell subpopulations in post-mortem brain tissue from the frontal cortex and hippocampus regions. The identification of AD-related Aβ species in brain cells could provide valuable insights into the disease.