Elucidating the neurodegnerative sequelae leading to VCID pathology.

Alexandria N Early,Erica M Weekman,Tiffany L Sudduth,Brittani R Price,Abigail E Woolums,Danielle Hawthorne,Charles E Seaks,Donna M Wilcock

Alzheimer's & dementia : the journal of the Alzheimer's Association（2021）

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摘要

Collectively, our findings suggest that astrocytic MMP9 may play an integral role in the mechanism associating homocysteine induced neuroinflammation with vascular pathogenesis leading to VCID. Continued study of the cell specificity and mechanism of MMP9 mediated vascular pathology will allow us to systematically target the various stages of disease and ultimately prevent the progression of VCID.

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vcid pathology,neurodegnerative sequelae

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