Genetic risk score for Alzheimer's disease in the Amish highlights differences in the genetic architecture compared to other European ancestry populations.

These results suggest that the Amish have a different genetic architecture than a general European-ancestry population, manifesting itself in less overall variation but also a lower relative importance of APOE. Since the prevalence of dementia in the Amish is similar to the general European population, this suggests the Amish may harbor unique AD genetic risk variants.