Targeted bisulfite sequencing analysis of candidate genes associated with Alzheimer's disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association(2021)
Abstract
This study builds on previous work that identified differential methylation in several genomic regions that were associated with Braak stage. By identifying the exact positions that are subjected to differential methylation and the potential impact these changes have on gene expression this work provides further evidence that dysregulation of methylation is associated with pathological changes in AD prefrontal cortex.
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Key words
alzheimer,bisulfite,candidate genes
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