The role of the RNA binding protein HnRNP K in the pathogenesis of frontotemporal lobar degeneration.
Alzheimer's & dementia : the journal of the Alzheimer's Association(2021)
摘要
The mislocalisation of hnRNP K from the nucleus to the cytoplasm in FTLD is associated with the inclusion of cryptic exons in multiple gene targets. This suggests that similarly to TDP-43, hnRNP K plays a crucial role in RNA processing and splicing regulation which when impaired could lead to transcriptional dysregulation and disease pathogenesis.
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