Polymorphisms in EPHX2 and CYP2J2 moderate associations between white matter hyperintensities and temporal lobe atrophy.

We identified potential moderation effects of genetic variation in EPHX2 and CYP2J2 on the association between WMH and temporal lobe atrophy across neurodegenerative diagnoses. The lack of SNP×SNP interactions suggests that these genes may act independently, consistent with WMH×SNP interaction effects that occurred in association with different anatomical WMH locations.