SR-B1’s Next Top Model: Structural Perspectives on the Functions of the HDL Receptor
Current Atherosclerosis Reports(2022)
摘要
Purpose of Review The binding of high-density lipoprotein (HDL) to its primary receptor, scavenger receptor class B type 1 (SR-B1), is critical for lowering plasma cholesterol levels and reducing cardiovascular disease risk. This review provides novel insights into how the structural elements of SR-B1 drive efficient function with an emphasis on bidirectional cholesterol transport. Recent Findings We have generated a new homology model of full-length human SR-B1 based on the recent resolution of the partial structures of other class B scavenger receptors. Interrogating this model against previously published observations allows us to generate structurally informed hypotheses about SR-B1’s ability to mediate HDL-cholesterol (HDL-C) transport. Furthermore, we provide a structural perspective as to why human variants of SR-B1 may result in impaired HDL-C clearance. Summary A comprehensive understanding of SR-B1’s structure–function relationships is critical to the development of therapeutic agents targeting SR-B1 and modulating cardiovascular disease risk.
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关键词
Scavenger receptor class B type 1, Cholesterol, High-density lipoprotein, Structural biology, Oligomerization, Cardiovascular disease
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