Liposomal amphotericin B related late-onset hyperphosphatemia in a pediatric patient with acute myeloid leukemia
JOURNAL OF ONCOLOGY PHARMACY PRACTICE(2022)
摘要
Introduction Children with acute myeloid leukemia (AML) are at risk for serious electrolyte abnormalities. Case report We reported a case of hyperphosphatemia in a child with acute myeloid leukemia who received liposomal amphotericin B (AMBL) for the treatment of an invasive fungal infection. The findings of this case suggest that cumulative dose accumulation due to long term AMBL treatment may result in late-onset hyperphosphatemia. Management and outcome This is the first case report in the literature that of late-onset hyperphosphatemia (day 56) in a patient with low-dose AMBL treatment (3-5 mg/kg/day) and normal renal function. Discussion We highlight the importance of increasing awareness of AMBL related hyperphosphatemia among healthcare providers.
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关键词
Amphotericin B, electrolyte abnormalities, hyperphosphatemia, liposomal amphotericin B, pediatric hematology
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