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Modeling the CRL4A Ligase Complex to Predict Target Protein Ubiquitination Induced by Cereblon-Recruiting PROTACs

Nan Bai,Kristin M. Riching,Aman Makaju,Hao Wu, Timothy M. Acker,Shu-Ching Ou,Yaru Zhang,Xiaomeng Shen, Daryl N. Bulloch,Huan Rui,Bradford W. Gibson,Danette L. Daniels,Marjeta Urh,Brooke M. Rock,Sara C. Humphreys

Journal of Biological Chemistry（2022）

引用 31|浏览15
关键词
PROTAC,degrader,CRL4A ligase complex,computational drug design,ubiquitination
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