Protective effects and regulatory mechanisms of melatonin in a neonatal mouse model of LPS-induced inflammation

Xinzhu Liu, Suyan Yao,Jing Bi,Deyu Zheng,Pan Wang

Neuroscience Letters（2022）

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摘要

•Lipopolysaccharide (LPS) treatment downregulates the relative expression levels of melatonin (MEL) receptors MT1 and MT2.•MEL can reduce LPS-induced neuroinflammatory responses and exhibit the relevant protective effects through MT1.

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关键词

Central nervous system inflammation,Melatonin,Organotypic brain slice culture,Lipopolysaccharide,MT1,MT2

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