Identifying Interpretable Clinical Subtypes withinHeterogeneous Dementia Clinic Population

Dementia is a highly heterogeneous neurodegenerative disorder. Differences in brain pathologies lead to significant variations in the clinical presentation and progression course of patients, increasing the need for individual progression predictions. Unsupervised cluster analysis on a dementia clinic population using the Clinical Dementia Rating (CDR) component scores uncovered subtypes with different risk of dementia progression. The distribution of the CDR components provide validation and interpretability regarding the cognitive characteristics of the identified subtypes.