A Longitudinal Mediational Investigation of Risk Pathways Among Cannabis Use, Interpersonal Trauma Exposure, and Trauma-Related Distress

Clinical Impact Statement The study suggests that cannabis use prior to college may increase risk for future interpersonal trauma exposure and development of trauma-related distress (TRD). Additionally, this study suggests that incoming college students with a greater history of interpersonal trauma exposure may be at increased risk for developing TRD and using greater amounts of cannabis use. Our results emphasize the importance of providing education about the risks of cannabis use to college students, as well as processing interpersonal traumas at they are a strong predictor of posttrauma psychopathology and greater amounts of cannabis use, which is a risk factor for problematic cannabis use. Objective: College students are at high risk for cannabis use, interpersonal trauma (IPT) exposure, and trauma-related distress (TRD). Two phenotypic etiologic models posited to explain associations between cannabis use and trauma-related phenotypes are the self-medication (trauma/TRD -> cannabis use) and high-risk (cannabis use -> trauma/TRD) hypotheses. The primary objective of the present study was to investigate direct and indirect associations among cannabis use, IPT exposure, and TRD above and beyond established covariates. Method: The current study used data from the first assessment (i.e., baseline survey at Year 1 Fall) and two follow-up assessments (i.e., Year 1 Spring and Year 2 Spring) from an ongoing longitudinal study on college behavioral health. Participants were 4 cohorts of college students (n = 9,889) who completed measures of demographics, substance use, IPT, and TRD. Indirect effects of IPT on cannabis through TRD (i.e., self-medication) and cannabis on TRD through IPT (i.e., high-risk), including tests of covariate effects (e.g., gender, age, race, cohort, alcohol, nicotine), were simultaneously estimated using a longitudinal mediation modeling framework. Results: Results suggest that more IPT exposure increases risk for TRD and subsequent nonexperimental (use 6+ times) cannabis use, and that experimental (use 1-5 times) and nonexperimental cannabis use increases risk for IPT exposure and subsequent TRD. Conclusions: Both the self-medication and high-risk hypotheses were supported. Findings support a bidirectional causal relationship between cannabis use and trauma-related phenotypes. Additionally, results highlight areas for colleges to intervene among students to help reduce cannabis use and create a safer environment.