Clinical and molecular profile of young adults with early-onset colorectal cancer: Experience from four Australian tertiary centers.
Asia-Pacific journal of clinical oncology(2022)
Abstract
The prevalence of KRAS and BRAF mutations in our cohort is similar to the overseas experience. Stage III disease at diagnosis, presence of PNI and BRAF mutation are adverse prognostic indicators. A better understanding of the molecular landscape is needed for this patient cohort, so as to better tailor prevention strategies, screening and treatment pathways.
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Key words
BRAF colorectal cancer,KRAS,early onset,young adults
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