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Metformin versus silymarin as hepatoprotective agents in mice fibrotic model caused by carbon tetrachloride

Z M M Omar, A A-N Ahmed, M H El-Bakry, M A Ahmed,A Hasan

Annales Pharmaceutiques Françaises（2022）

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Abstract
•Both silymarin and metformin exhibited a significant decrease in fibrotic changes.•Silymarin is more beneficial with a significant difference.•Injection of CCl4 for 7 weeks originated a significant liver fibrosis in mice.
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Key words
CCl4,Liver fibrosis,Metformin,Silymarin
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