The Novel KLF4/BIG1 Regulates LPS-mediated Neuro-inflammation and Migration in BV2 Cells via PI3K/Akt/NF-kB Signaling Pathway

Zhijun You, Zhenzhen Yang,Shuang Cao,Shouheng Deng,Yi Chen

Neuroscience（2022）

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摘要

•BIG1 promotes LPS-mediated inflammatory cytokines production.•BIG1 facilitated LPS-mediated BV2 cell migration.•Activation of PI3K/Akt pathway reversed the protective roles of BIG1 silencing in inflammation and migration.•KLF4 transcriptionally regulated BIG1 expression in BV2 cells.•Ectopic expression of BIG1 partly reversed the biological activities of KLF4.

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关键词

BIG1,neuro-inflammation,migration,BV2 cells,PI3K/Akt/NF-kB signaling pathway

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