Anti-allergic, anti-asthmatic and anti-inflammatory effects of an oxazolidinone hydroxamic acid derivative (PH-251) – A novel dual inhibitor of 5-lipoxygenase and mast cell degranulation

Charles I Ezeamuzie,Muddanna S Rao,Ahmed Z El-Hashim, Elizabeth Philip,Oludotun A Phillips

International Immunopharmacology（2022）

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摘要

•PH-251 is a pharmacologically active oxazolidinone hydroxamic acid derivative.•PH-251 is a novel dual inhibitor of 5-Lipoxygenase and mast cell degranulation.•PH-251 has anti-allergic, anti-asthmatic and anti-inflammatory effects.

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5-LO,AHR,AUC,BALF,Beta-Hexos,BMMC,CI,Dexa,DNP-BSA,DSCG,FBS,IC50,IgE,LT,LTC4,Ova,PEG,PH-251,RL,Veh

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