Increased risk of infection with SARS-CoV-2 Omicron BA.1 compared with Delta in vaccinated and previously infected individuals, the Netherlands, 22 November 2021 to 19 January 2022.

Dirk Eggink,Stijn P Andeweg,Harry Vennema,Noortje van Maarseveen,Klaas Vermaas,Boris Vlaemynck,Raf Schepers,Arianne B van Gageldonk-Lafeber,Susan van den Hof,Chantal Bem Reusken,Mirjam J Knol

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin（2022）

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摘要

Infections with the Omicron SARS-CoV-2 variant are rapidly increasing worldwide. Among 174,349 SARS-CoV-2-infected individuals (≥ 12 years), we observed an increased risk of S gene target failure, predictive of the Omicron variant, in vaccinated (odds ratio (OR): 3.6; 95% confidence interval (CI): 3.4-3.7) and previously infected individuals (OR: 4.2; 95% CI: 3.8-4.7) compared with infected naïve individuals. This suggests vaccine- or infection-induced immunity against SARS-CoV-2 infections is less effective against the Omicron than the Delta variant.

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关键词

SARS-CoV-2 Omicron Variant of Concern Vaccine escape,air-borne infections,epidemiology,laboratory,severe acute respiratory syndrome - SARS,vaccines and immunisation,viral infections

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