Giardia duodenalis cysteine proteases cleave proteinase-activated receptor-2 to regulate intestinal goblet cell mucin gene expression

Elena Fekete,Thibault Allain, Christina B. Amat,Koichiro Mihara,Mahmoud Saifeddine,Morley D. Hollenberg,Kris Chadee,Andre G. Buret

International Journal for Parasitology（2022）

引用 6|浏览10

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摘要

•Giardia duodenalis cysteine proteases cleave PAR1 and PAR2 at the N-terminus with isolate-dependent efficiency.•Canonical PAR2 signaling regulates MUC2 mucin gene expression in intestinal goblet cells.•Relative levels of cysteine protease activity between Giardia isolates correlates with PAR cleavage rate.•Isolate-dependent effects on mucin gene expression correlate with Giardia cysteine protease activity and PAR cleavage rate.

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关键词

Giardia,Mucus,Goblet cell,Protease,Protease-activated receptor,PAR2

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