Effects of oral wound on the neutrophil lineage in murine bone-marrow: Modulation mechanism hindered by chlorhexidine

Bruno Marques Vieira, Narciso Dias de Almeida Neto, Lucas Everton Simões, Eduardo Jorge Feres-Filho,Maria Ignez C Gaspar-Elsas,Pedro Xavier-Elsas

International Immunopharmacology(2022)

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摘要
•Oral wound leads to increased neutrophilia and decreasedneutropoietic potential.•Washing the oral cavity with chlorhexidine abolished the bone-marrow neutrophilia.•Matched treatment is important to reduce neutrophilia.•Endogenous Glucocorticoids aren’t involved in this model.
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关键词
Neutrophil,Oral Wound,Neutropoiesis,Chlorhexidine,Glucocorticoid
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