Metastatic tumor antigen 1 contributes to hepatocarcinogenesis posttranscriptionally through RNA-binding function.

Yung-Tsung Li,Chun-Jen Liu,Jia-Horng Kao, Li-Feng Lin, Hui-Chu Tu,Chih-Chiang Wang, Po-Hsi Huang,Huei-Ru Cheng,Pei-Jer Chen,Ding-Shinn Chen,Hui-Lin Wu

Hepatology (Baltimore, Md.)（2023）

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摘要

MTA1 is a generic RNA-binding protein. Cytoplasmic MTA1 and its binding to MYC is associated with early recurrence in patients with HBV-HCC. This function enables it to regulate gene expression posttranscriptionally and contributes to hepatocarcinogenesis.

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关键词

RNA stability,carcinogenesis,post-transcriptional control,self-renewal and anchorage-independent growth,tumorigenic capacity

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