Differentially Expressed Mutant Genes Reveal Potential Prognostic Markers For Lung Adenocarcinoma.

Lung adenocarcinoma is a serious lung cancer, belonging to the category of non-small cell lung cancer, accounting for 30 to 35 percent of the total, and lung adenocarcinoma is more common in women and non-smoking patients. In this study, LUAD samples of mutation genes and RNA-seq expression dataset were retrieved from TCGA database. WGCNA, Cox regression analysis were used to classify melanoma prognosis. It revealed that eleven mutant and differentially expressed prognosis biomarkers were significantly associated with the prognosis of patients. Therefore, detecting these gene mutations and exploring their corresponding expression could be valuable in predicting the prognosis of patients. The results of the high-throughput data mining provide important fundamental bioinformatics information and a relevant theoretical basis for further exploring the molecular pathogenesis of LUAD and assessing the prognosis of patients.