Boosting Boundary Representation for Gland Instance Segmentation.

Accurate and automated gland instance segmentation on histology images can assist pathologists to analyze the malignancy degree of adenocarcinoma. Recently, deep-learning-based segmentation networks have been significantly developed to achieve this goal. However, the gland instances are generally proximate to each other and have indiscernible boundaries (i.e., homogeneous intensity values). Most of the existed networks do not define discriminative boundaries representation as context information, resulting in segmenting proximate instances incorrectly. In this paper, to improve the segmentation accuracy between proximate instances, we propose a Boundary Definition Module to boost boundaries feature representation by the guidance of the intra-and-extra glandular features. Moreover, we propose to use the Gumbel-Softmax distribution estimator to clarify the final prediction of boundaries further. Finally, we embed the Boundary Definition Module and Gumbel-Softmax distribution estimator into the gland instance network(FullNet) for performance verification. Experiments on the 2015 MICCAI Gland Segmentation Challenge dataset demonstrate that our proposed method achieves state-of-the-art performance.