Development of the gonadotropin-releasing hormone system

Anne H Duittoz,Paolo E Forni,Paolo Giacobini,Matan Golan,Patrice Mollard,Ariel L Negrón,Sally Radovick,Susan Wray

JOURNAL OF NEUROENDOCRINOLOGY（2022）

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摘要

This review summarizes the current understanding of the development of the neuroendocrine gonadotropin-releasing hormone (GnRH) system, including discussion on open questions regarding (1) transcriptional regulation of the Gnrh1 gene; (2) prenatal development of the GnRH1 system in rodents and humans; and (3) paracrine and synaptic communication during migration of the GnRH cells.

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关键词

development, GnRH, guidance cues, migratory pathway, olfactory ensheathing cells, olfactory placode, synaptic and paracrine signals, terminal nerve, transcription factors

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