TEMPERATURE TRAJECTORY SUBPHENOTYPES AND THE IMMUNOINFLAMMATORY RESPONSE IN PEDIATRIC SEPSIS

Nadir Yehya,Julie C Fitzgerald,Katie Hayes,Donglan Zhang,Jenny Bush,Natalka Koterba,Fang Chen,Florin Tuluc,David T Teachey,Fran Balamuth,Simon F Lacey,Jan Joseph Melenhorst,Scott L Weiss

CRITICAL CARE MEDICINE（2022）

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摘要

Critically ill septic children can be categorized into temperature trajectory-defined sub-phenotypes that parallel adult sepsis. Hypothermic children exhibit a blunted cytokine and chemokine profile. Group-based trajectory modeling has utility for identifying subtypes of clinical syndromes by incorporating readily available longitudinal data, rather than relying on inputs from a single timepoint.

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关键词

Children, endotype, sepsis, subclassification, trajectory modelling

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