Inhibitor GSK690693 extends Drosophila lifespan via reduce AKT signaling pathway

Xingyi Cheng,Meng Xie,Lu Luo,Yao Tian,Guixiang Yu, Qi Wu,Xiaolan Fan,Deying Yang,Xueping Mao,Uma Gaur,Mingyao Yang

Mechanisms of Ageing and Development（2022）

Cited 5|Views3

No score

Abstract

•AKT inhibitor GSK690693 can extend lifespan in Drosophila without the induction of hyperglycemia.•GSK690693 can improve oxidative resistance, intestinal integrity and autophagy in Drosophila•These beneficial effects are achieved by acting on critical targets in AKT signaling pathway.

Translated text

Key words

GSK690693,Anti-aging,Autophagy,AKT,Drosophila

AI Read Science

Must-Reading Tree

Example

Generate MRT to find the research sequence of this paper

Chat Paper

Summary is being generated by the instructions you defined