Solid lipid nanoparticles loaded with curcumin: development and in vitro toxicity against CT26 cells

Rayane Ganassin,Victor Carlos Mello da Silva,Victor Hugo Sousa Araujo, Giulia Rosa Tavares,Patrícia Bento da Silva,Paolin Rocio Cáceres-Vélez,Joaquin E Martínez Porcel,Mosar Corrêa Rodrigues,Patrizia Andreozzi,Richard Perosa Fernandes,Bruno Fonseca-Santos,Sergio Moya,Ricardo Bentes Azevedo,Marlus Chorilli,Luis Alexandre Muehlmann

NANOMEDICINE（2022）

Cited 7|Views29

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Abstract

Aim: To develop a new curcumin carrier consisting of murumuru butter nanoparticles (SLN-Cs). Methods: A phase-inversion temperature method was used to produce SLN-Cs. The interaction of SLN-Cs with murine colon adenocarcinoma (CT26) cells in vitro was analyzed by confocal microscopy. Results: Stable SLN-Cs with a high curcumin-loading capacity were obtained. The SLN-Cs were more toxic to CT26 than free curcumin. Fluorescence microscopy images showed the SLN-Cs to be taken up by CT26 cells in vitro. Conclusion: These results indicate that SLN-Cs are suitable carriers of curcumin in aqueous media.

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Key words

cancer, colloid, colon adenocarcinoma, drug delivery, murumuru butter

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