Monocarboxylate transporter 4 inhibition potentiates hepatocellular carcinoma immunotherapy through enhancing T cell infiltration and immune attack.

Hepatology (Baltimore, Md.)（2022）

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摘要

Our results revealed that lactate exportation by MCT4 has a tumor-intrinsic function in generating an immunosuppressive HCC environment and demonstrated the proof of the concept of targeting MCT4 in tailoring HCC immunotherapeutic approaches.

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关键词

Chemokine,Hepatocellular carcinoma,Lactate,Monocarboxylate transporter 4,PD-1 blockade

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