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Mining LTR-retrotransposon genes for mRNA delivery

Marco Herrera-Barrera,Gaurav Sahay

Trends in pharmacological sciences（2022）

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Abstract
RNA-based therapeutics commonly use exogenous components to shuttle their cargo, leading to nonselectivity or immunogenicity. Segel et al. have elucidated an endogenous modular retroviral-like delivery system capable of encapsulating mRNA, which elicits effective transport inside cells, priming the development of endogenous vectors for gene delivery for amelioration of disease.
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