Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Transmission Dynamics and Immune Responses in a Household of Vaccinated Persons

Jamin Liu,Matthew T. Laurie,Luis Rubio,Sara E. Vazquez,Sara Sunshine,Anthea M. Mitchell, Matthias Hapte-Selassie,Sabrina A. Mann,Genay Pilarowski,Douglas Black,Carina Marquez,Susana Rojas,Michail S. Lionakis,Maya Petersen,Jeffrey D. Whitman,Vivek Jain,Mark Anderson,Diane Havlir,Joseph DeRisi

CLINICAL INFECTIOUS DISEASES（2022）

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摘要

While SARS-CoV-2 vaccines prevent severe disease effectively, postvaccination "breakthrough" COVID-19 infections and transmission among vaccinated individuals remain ongoing concerns. We present an in-depth characterization of transmission and immunity among vaccinated individuals in a household, revealing complex dynamics and unappreciated comorbidities, including autoimmunity to type 1 interferon in the presumptive index case.

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SARS-CoV-2,antibody neutralization,breakthrough infection,anti,interferon autoantibody,autoimmunity

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