Amantadine-assembled nanostimulator enhances dimeric RBD antigen-elicited cross-neutralization against SARS-CoV-2 strains

Ye Zhang,Ruixin Wang,Chunyan He,Yu-Fang Zhang, Zhongrui Luo,Jia Luo,Sisi Chen,Yu Jin,Bowen Xie,Ye Liu

Nano Today（2022）

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摘要

•Developing a new nanostimulator to enhance dimeric RBD-elicited cross-neutralization against SARS-CoV-2 strains.•Verifying that amantadine-assembled nanostimulator (AAS) enhances host immunity by RIG-I-like receptor signaling pathway.•Highlighting the convenience and robustness of AAS application.

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关键词

Amantadine assembly,Dimeric RBD antigen,RLR Signaling pathway,Cross-neutralization,SARS-CoV-2

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