Critical changes in hypothalamic gene networks in response to pancreatic cancer as found by single-cell RNA sequencing

Christian Huisman,Mason A Norgard,Peter R Levasseur,Stephanie M Krasnow,Monique G P van der Wijst,Brennan Olson,Daniel L Marks

Molecular Metabolism（2022）

引用 6|浏览10

暂无评分

摘要

•Single-cell RNA-sequencing reveals hypothalamic response to cancer cachexia.•Tumor-derived factors induce endothelial inflammation in the hypothalamus.•Plin4 is a novel cachexia marker in oligodendrocytes for cancer cachexia.•Novel hunger hormone LCN2 activates food-intake decreasing POMC neurons.•Inflammatory and a moderating microglia in the hypothalamus respond to cancer cachexia.

查看译文

关键词

Cachexia models,Pancreatic cancer,Food intake regulation,Endothelial inflammation,scRNA-seq of the central nervous system,Neuroinflammation

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要