High Level Forebrain Expression of Active Tau Kinase p38γ Exacerbates Cognitive Dysfunction in Aged APP-transgenic Alzheimer’s Mice

Prita R Asih,Kristie Stefanoska,Emmanuel Prikas,Arne Ittner

Neuroscience（2022）

引用 1|浏览8

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摘要

•High level expression of active p38γ after direct viral delivery into forebrains of aged APP23 mice.•High p38γ activity is associated with cognitive impairment without aggravated astro- or microgliosis.•Results support the need for adjustable expression systems for p38γ-based gene therapy.

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关键词

Alzheimer’s disease,gene therapy,microtubule-associated protein tau,mitogen-activated protein kinase,p38,neuroprotection

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