Osmium(vi) nitride triggers mitochondria-induced oncosis and apoptosis

Meng Ye,Wan-Qiong Huang,Zi-Xin Li,Chuan-Xian Wang,Tao Liu,YunZhou Chen,Catherine Hong-Huan Hor,Wai-Lun Man,Wen-Xiu Ni

Chemical Communications（2022）

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摘要

We report a new osmium(vi) nitrido complex bearing a nonplanar tetradentate ligand with potent anticancer activity. This complex causes mitochondrial damage, which induces liver cancer cell death via oncosis and apoptosis. This is the first osmium-based anticancer candidate that induces oncosis.

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关键词

apoptosis,oncosis,mitochondria-induced

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