Electrophysiological heterogeneity in large populations of rabbit ventricular cardiomyocytes.
Cardiovascular research(2022)
Abstract
Modelling the measured range of inter-cell APDs required a larger range of key Gmax values indicating that ventricular tissue has considerable inter-cell variation in channel/pump/exchanger activity. AP morphology is retained by relationships linking specific ionic conductances. These interrelationships are necessary for stable repolarization despite large inter-cell variation of individual conductances and this explains the variable sensitivity to ion channel block.
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Key words
Electrophysiology,Heterogeneity,Repolarization,Ventricle
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