Incidence of Glaucoma Progression and Rate of Visual Field Deterioration in a Cohort of Urban Ghanaians
Journal of glaucoma(2022)
摘要
Precis:The annual incidence of glaucoma progression (9.7%) and rates of visual field mean deviation (MD) change in progressors (-1.02 +/- 0.06 dB/y) are high in a small cohort of urban Ghanaians. Purpose:To report the incidence of glaucoma progression and the rate of visual field deterioration in a small cohort of Ghanaians. Methods:One hundred ten subjects (204 eyes) diagnosed with glaucoma at a baseline population-based screening examination were re-examined a mean of 8.3 +/- 0.8 years later. Eyes were classified as having progressed if the optic disc alone, visual field alone or both showed significant glaucomatous changes on follow-up. Visual field MD was used to calculate the rate of visual field progression. Results:Progression was observed in 89 (80.9%, 9.7%/year) subjects (130 eyes). Progression occurred in 32 (31.7%, 3.8%/year) subjects by optic disc alone (46 eyes), 38 (44.7%, 5.4%/year) subjects by visual field alone (58 eyes), and 19 (25.0%, 3.0%/year) subjects by both modalities (26 eyes). The average rate of change in MD differed significantly between progressors (-1.02 +/- 1.06 dB/y) and nonprogressors (+0.089 +/- 0.49 dB/y), P=0.001. The rate of visual field worsening was greater among those who were classified as having progressed by both structure and function (-1.29 +/- 0.68 dB/y) and by function alone (-1.21 +/- 1.20 dB/y) than by structure alone (-0.55 +/- 0.76 dB/y). Progression was significantly associated with older age [odds ratio (OR), 1.42; P<0.001] and higher baseline intraocular pressure (OR, 1.18; P=0.002). Factors associated with rate of MD change were baseline older age (OR, 1.66; P=0.003), higher intraocular pressure (OR, 2.81; P=0.007), better visual field MD (OR, 1.41; P=0.004), and systemic hypertension (OR, 1.15; P=0.029). Conclusion:The incidence and rate of visual field progression are high in this longitudinal study of Ghanaian subjects with glaucoma. The findings may have important clinical and public health policy ramifications.
更多查看译文
关键词
incidence,glaucoma progression,visual field progression,optic disc progression,rate of change
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要